Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdkn1c  cyclin dependent kinase inhibitor 1C   (Synonyms: CDKI, Kip2, p57Kip2)
Results	Reference
1	J:147778 Bilodeau S, Roussel-Gervais A, Drouin J, Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells. Mol Cell Biol. 2009 Apr;29(7):1895-908
1	J:139969 Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU, Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol. 2008 Sep 15;321(2):420-33
1	J:237816 Calderon MJ, Ploegman AG, Bailey B, Jung DO, Navratil AM, Ellsworth BS, Loss of Foxm1 Results in Reduced Somatotrope Cell Number during Mouse Embryogenesis. PLoS One. 2015;10(6):e0128942
1	J:223109 Choi JJ, Ting CT, Trogrlic L, Milevski SV, Familari M, Martinez G, de Iongh RU, A role for smoothened during murine lens and cornea development. PLoS One. 2014;9(9):e108037
1	J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
1	J:115946 Dokras A, Hoffmann DS, Eastvold JS, Kienzle MF, Gruman LM, Kirby PA, Weiss RM, Davisson RL, Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia. Biol Reprod. 2006 Dec;75(6):899-907
1	J:241179 Duquesnes N, Callot C, Jeannot P, Daburon V, Nakayama KI, Manenti S, Davy A, Besson A, p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome. J Pathol. 2016 Jul;239(3):250-61
1	J:63217 Dyer MA, Cepko CL, p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development. 2000 Aug;127(16):3593-605
1	J:127074 Glickstein SB, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, Ross ME, Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007 Nov;134(22):4083-93
1	J:117093 Gui H, Li S, Matise MP, A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol. 2007 Jan 1;301(1):14-26
1	J:239361 Guimaraes-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC, HIF1alpha Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08;33(5):507-21
1	J:235665 He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A, Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016 Jun 1;143(11):1937-47
1	J:332137 Hu H, Duan Y, Wang K, Fu H, Liao Y, Wang T, Zhang Z, Kang F, Zhang B, Zhang H, Huo F, Yin Y, Chen G, Hu H, Cai H, Tian W, Li Z, Dental niche cells directly contribute to tooth reconstitution and morphogenesis. Cell Rep. 2022 Dec 6;41(10):111737
1	J:101095 Kase S, Yoshida K, Ikeda H, Harada T, Harada C, Imaki J, Ohgami K, Shiratori K, Nakayama KI, Nakayama K, Ohno S, Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens. Curr Eye Res. 2005 Jun;30(6):437-42
1	J:208421 Klimova L, Kozmik Z, Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
1	J:175828 Komatsu Y, Kaartinen V, Mishina Y, Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. Development. 2011 Sep;138(18):3915-20
1	J:89721 MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM, The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest. 2004 May;113(9):1334-43
1*	J:263032 Magella B, Mahoney R, Adam M, Potter SS, Reduced Abd-B Hox function during kidney development results in lineage infidelity. Dev Biol. 2018 Jun 15;438(2):84-93
1	J:179730 Mairet-Coello G, Tury A, Van Buskirk E, Robinson K, Genestine M, Dicicco-Bloom E, p57KIP2 regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex. Development. 2012 Feb;139(3):475-87
1*	J:331971 Martynova E, Zhao Y, Xie Q, Zheng D, Cvekl A, Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Open Biol. 2019 Dec;9(12):190220
1	J:178174 Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI, Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol. 2011 Oct;31(20):4176-92
1	J:157341 Monahan P, Rybak S, Raetzman LT, The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary. Endocrinology. 2009 Sep;150(9):4386-94
1*	J:74094 Nagahama H, Hatakeyama S, Nakayama K, Nagata M, Tomita K, Nakayama K, Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development. Anat Embryol (Berl). 2001 Feb;203(2):77-87
1	J:109091 Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F, p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev. 2006 Jun 1;20(11):1511-24
1	J:245925 Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C, The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 2017 Nov 01;144(21):3917-3931
1	J:138714 Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL, Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008 Sep 1;321(1):111-22
1*	J:152946 Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA, Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
1	J:230957 Sugiyama Y, Shelley EJ, Badouel C, McNeill H, McAvoy JW, Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4099-107
1	J:343554 Sun Q, Li J, Ma J, Zheng Y, Ju R, Li X, Ren X, Huang L, Chen R, Tan X, Luo L, JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):15
1	J:186005 Tury A, Mairet-Coello G, DiCicco-Bloom E, The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors. Cereb Cortex. 2011 Aug;21(8):1840-56
1	J:194895 Upadhya D, Ogata M, Reneker LW, MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013 Apr;140(7):1573-82
1*	J:72601 Westbury J, Watkins M, Ferguson-Smith AC, Smith J, Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis. Mech Dev. 2001 Nov;109(1):83-9
1	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
1	J:316796 Zhao M, Mei T, Shang B, Zou B, Lian Q, Xu W, Wu K, Lai Y, Liu C, Wei L, Zhu J, Zhang K, Liu Y, Zhao L, Defect of LSS Disrupts Lens Development in Cataractogenesis. Front Cell Dev Biol. 2021;9:788422